The Wildcats (19-0, 6-0 Southeastern Conference) pulled away with 14 straight points after the Gamecocks (10-8, 1-5) took their last lead at 24-23 with 4:31 in the opening half.
Kentucky's lead never fell below double digits after that.
The Wildcats were 19-0 in 2010, Calipari's first season in Kentucky when he had NBA standouts John Wall and DeMarcus Cousins. That run ended in this building with South Carolina's 68-62 stunner. The sold out crowd was just as loud after Sindarius Thornwell's 3-pointer put the Gamecocks out front.
Tyler Ulis started the comeback for Kentucky with a steal and basket before Booker made two fouls shots and a jam and the Wildcats were on their way.