Quick finished with 174 yards — 111 of them on the TD grabs — on seven catches for the Cardinals (3-1), who got a touchdown run from L.J. Scott.
Gardner threw for 295 yards, but he and Scott both left the game with injuries. Louisville led 28-0 late in the half, giving the Cardinals what was 100 unanswered points in the series after topping FIU 72-0 last season.
Austin Taylor kicked a 28-yard field goal for FIU (1-3). Starting quarterback Alex McGough left in the third quarter after his third turnover of the night.
Kickoff was delayed 1 hour, 5 minutes because of severe weather in the area.