Lee finished 8 of 12 from the floor and scored 15 in the first half. He also added eight rebounds.
The Cardinals (4-0) used their size to dominate inside, scoring 28 of their first 30 points in the paint. St. Francis managed only four points in the post in the first half. Louisville shot 19 of 31 (61 percent) en route to 43-24 halftime lead with 32 points coming in the paint.
Glenn Sanabria and Tyreek Jewell each scored 11 points for St. Francis (1-3).
Louisville played five players 6-9 or taller while the Terriers' tallest starter, 6-7 Amdy Fall, fouled out without scoring. The Cardinals finished with a 56-12 advantage on points in the paint.