Brion Whitley added a career-high 10 and KJ Williams blocked two shots and scored 10 points for the Racers (6-1), who made 11 of 26 3-pointers and held the Salukis to 31 percent shooting.
The Racers hit three 3-pointers in their opening 13-5 run and Murray State pulled away on 20-3 run capped by Brown's 3 and led 49-18 at halftime.
It's the lowest amount of points the Racers have allowed in a half since giving up 16 points to SIU Edwardsville on Feb. 12, 2015.
Williams dunked for a 59-29 Murray State lead early in the second half and the Racers led 75-45 with 4:30 to play after scoring seven straight.
Eric McGill scored 19 points and grabbed nine rebounds, Aaron Cook added 14 points and Sean Lloyd Jr. scored 11 for Southern Illinois (7-4), which saw its five-game win streak end.
