The Cardinals trailed for the much of the game before their newcomers stepped to make all six combined shots, with many in clutch moments. Louisville shot 70 percent after halftime to win its first regular season contest since longtime coach Rick Pitino was fired last month in the wake of a national federal investigation of corruption in college basketball.
Perry scored 12 of his 17 points after halftime, while Nwora was 3-for-3 from long range for 10 points. Adel meanwhile went 9 of 17 from the field to help the Cardinals win their season opener before 18,304.
Jaire Grayer had 20 points and Justin Kier 18 for George Mason (1-1), which led 46-45 with 11 minutes remaining before Louisville took control.
