Jackson capped off a September to remember with another solid effort against an over-matched opponent.
The sophomore completed 24 of 44 passes for a career-high 417 yards against a Marshall secondary whose most experienced player had five starts. Jackson also ran for 62 yards.
Louisville (4-0) didn't slow down against a non-conference opponent on the road a week after beating Florida State 63-20 at home.
The Cardinals raced to a 35-7 halftime lead on Marshall and cruised in the second half to break a four-game losing streak to the Thundering Herd. Jackson's scoring passes covered 71, 8, 30, 8 and 51 yards.
Marshall (1-2) was limited to 207 yards of offense in the first start for freshman quarterback Garet Morrell. Chase Litton missed the game with an undisclosed injury that was announced an hour before kickoff.
