Jackson's 3-pointer with 7:52 left gave the Irish a 53-48 lead. He then added consecutive jumpers to twice provide nine-point cushions that sealed the victory for the Fighting Irish (25-5, 13-4 ACC).
He also had plenty of help from other teammates such as Bonzie Colson, who made a big jumper down the stretch en route to 17 points on 7-of-7 shooting.
Jerian Grant added 12 points and Steve Vasturia 10 as Notre Dame finished 54 percent from the field and made 20 of 25 from the free-throw line.
Montrezl Harrell had 23 points for the Cardinals (23-7, 11-6), but missed several free throws as they tried to rally. Louisville finished 11 of 18 from the line.
