Listed fourth on the depth chart, Radcliff's first career 100-yard effort on 17 carries was much needed as Louisville (4-1, 2-1 ACC) overcame three lost fumbles and 11 penalties. The Cardinals defense kept Wake Forest (2-3, 0-1) to minus-22 yards rushing and had three takeaways, both setting up touchdowns. Louisville also had eight sacks.
Wake Forest scored first on Mike Weaver's 43-yard field goal late in the first quarter and retook the lead at 10-7 with 8:32 remaining in the third quarter following nose tackle Tylor Harris's fumble recovery in the Louisville end zone for a touchdown.
Radcliff's 16-yard score with less than 12 minutes left followed his 29-yard second-quarter touchdown.
