St. Louis scored 18 combined runs in two games to close out a sweep over San Diego and had 15 in splitting the first two against Arizona.
The Cardinals kept bashing, knocking around Patrick Corbin (1-3) and finishing with 14 hits, four by Stephen Piscotty.
Aledmys Diaz homered, scored three runs and had two RBIs for the Cardinals, who have won four of five. Piscotty, Matt Carpenter and Matt Holiday also drove in two runs each.
Wainwright (1-3) gave up homers to Brandon Drury and Paul Goldschmidt but ended his worst start since 2012 behind the Cardinals' big run support.
