After wind gusts threatening 40 mph pummeled the morning starters, Hoffman faced steady 15 mph wind in the afternoon at TPC San Antonio. He had the lone bogey-free round, birdieing Nos. 2, 3, 9, 11 and 17.
The winner last year in Mexico at the start of the wraparound season, Hoffman has eight top-10 finishes in nine appearances in San Antonio.
Aaron Baddeley was second after a 68.
Max Homa had a 69, and Phil Mickelson and Ryan Palmer shot 70.