Ben Zobrist added three RBIs for Chicago as the defending World Series champions won for the fifth time in six games. Anthony Rizzo had three hits to extend his hitting streak to 13 games. Kyle Schwarber, Kris Bryant and Miguel Montero all had two hits apiece for the Cubs.
Chicago scored four runs with two outs in the first inning off Chad Kuhl (1-2) and added five more in the second to give Brett Anderson (2-0) all the breathing room he would need.
Anderson struggled at times with his command, walking six in six innings while striking out three and allowed three runs, one earned.