Goldschmidt's 19th homer off Simon (12-6) gave the Diamondbacks two of three in the series. Simon has gone 0-3 since his first All-Star selection. Didi Gregorius added a two-run homer in the ninth.
The Reds fell to 2-10 since the All-Star break. Devin Mesoraco's three-run homer in the ninth off Addison Reed ended a streak of 11 straight games with three runs or fewer, Cincinnati's longest such stretch of futility since 1967.
