Huff returned the opening kickoff 107 yards, McCoy ran for 130 yards and the Eagles beat the Tennessee Titans 43-24 on Sunday.
Mark Sanchez threw for 307 yards and one touchdown in his third start for the injured Nick Foles. He has 300 yards passing in three straight games, tying a team record.
Rookie Zach Mettenberger had 345 yards passing and two TDs and Delanie Walker had 155 yards receiving for the Titans (2-9).
Now, the Eagles (8-3) can shift their focus to the Cowboys (7-3) for a first-place showdown on Thanksgiving. The top two teams in the NFC East will play twice in 18 days, starting with Thursday's game at Dallas.
Coming off a 53-20 loss at Green Bay, the Eagles jumped ahead of the lowly Titans immediately and never let up.