Newton got a big boost from a defense that returned two of Romo's three interceptions for touchdowns, and the Panthers ran their NFL-best winning streak to 15 regular-season games with a 33-14 victory over the Dallas Cowboys on Thursday.
Romo injured the same left collarbone that sidelined him for all seven games of a losing streak that damaged the playoff hopes for the defending NFC East champion Cowboys (3-8).
Carolina linebacker Luke Kuechly intercepted two straight passes by Romo, returning the first 32 yards for a touchdown.
Safety Kurt Coleman picked off Romo's second pass of the game and took it back 36 yards for the score as the Panthers became the 16th NFL team to start a season 11-0 in a Thanksgiving debut.