A night after the Giants opened with a 7-1 victory for their seventh straight Series win, Gregor Blanco led off the game with a home run against hard-throwing rookie Yordano Ventura. Brandon Belt tied the score 2-all with an RBI double in the fourth.
Butler's single off Jean Machi drove in his second run of the night and put the Royals ahead 3-2. Perez lined a two-run double to the left-center wall for a three-run lead, and Infante homered into the left-field bullpen off Hunter Strickland.
Game 3 is Friday night in San Francisco.
