The 23-year-old Wisler (5-11) allowed a run and two hits with four strikeouts and three walks in eight innings. Jim Johnson pitched the ninth inning for his 12th save.
Paul Goldschmidt broke up Wisler's no-hit bid with a leadoff single in the seventh. Goldschmidt scored on Chris Owings' groundout.
Robbie Ray (7-12) had won his last two starts, but his pitch count surpassed 100 before the fifth inning was over. He allowed two runs and six hits with four walks and seven strikeouts in five innings.
The Braves scored twice in the third when the first three hitters singled. Freddie Freeman drove in Ender Inciarte, then Nick Markakis beat out a ground ball to avoid a double play that allowed Adonis Garcia to score from third base.
