Akers ran 29 times for 112 yards for Florida State (2-2, 1-1 Atlantic Coast Conference), which had 522 offensive yards.
The Seminoles squandered a 21-0 lead after the first quarter. Louisville's Malik Cunningham threw for two touchdowns and ran for another as the Cardinals were able to storm back for a short-lived fourth-quarter lead.
Hornibrook put the Seminoles ahead for good, 28-24, on a touchdown pass to Tamorrion Terry with 7:25 left in the game.
Cunningham completed 16 of 27 passes for a career-high 286 yards but Louisville (2-2, 0-1) missed out on its first ACC win since 2017.
Florida State lost quarterback James Blackman to injury in the third quarter. Hornibrook, who had a first-quarter touchdown pass, stepped in and completed 15 of 20 passes for 255 yards.
Ricky Aguayo missed field-goal attempts from 51, 47 and 41 for the Seminoles.
UP NEXT
Louisville hosts Boston College on Oct. 5.
Florida State hosts NC State on Saturday.
