Pekka Rinne made 28 saves and James Neal, Calle Jarnkrok and Shea Weber also scored to help Nashville end a three-game home losing streak.
Joe Thornton and Logan Couture scored for the Sharks. Their 17-8-2 road record is the best in the Western Conference, and the Sharks fell to 9-2-2 in their last 13 games.
Rinne, a Vezina Trophy finalist last season, regained his form after allowing six goals in a loss Thursday night to Philadelphia.
San Jose goalie Martin Jones allowed five goals on 29 shots. He was 8-1-1 in his previous 10 starts and has an NHL-best 15-5-2 road record.
