Yasmani Grandal and Eloy Jiménez hit sacrifice flies and Chicago scored four runs in the ninth inning - three charged to ineffective Cleveland closer Brad Hand - to give the White Sox a 4-0 win over the Indians.
Cleveland starter Zach Plesac shut out the White Sox for eight innings and struck out a career-high 11.
But Hand couldn't keep the White Sox off the board in the ninth.
Chicago rookie Luis Robert had a two-run single in the inning as Chicago snapped a three-game losing streak and salvaged one game in the series.
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White Sox Score Late, Top Indians 4-0
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