Kentucky State Police said the crash occurred Thursday night at the intersection of US 68 and KY 139/South Road near Cadiz.
Officers said that 20-year-old Emily Lyons of Staffordsville failed to yield the right of way to 56-year old Jon McGraw of Cadiz. McGraw was unable to stop in time and struck the passenger side of Lyons' vehicle.
Lyons, McGraw, and a passenger in Lyons' vehicle, 32-year-old Matthew Cook of Wittensville, were all transported to Trigg County Hospital. A short time later Lyons and Cook died due to their injuries.
Autopsies are scheduled for Friday in Louisville.